Neurodegenerative disorders are some of the most feared illnesses in modern society, with
no effective treatments to slow or halt this neurodegeneration. Several decades after the …

Experimental research over the past decade has supported the critical role of astrocytes
activated by different types of injury and the pathophysiological processes that underlie the …

Fragment-based lead discovery (FBLD) is becoming an increasingly important method in
drug development. We have explored the potential to complement NMR-based biophysical …

Introduction Sleep deprivation and electroconvulsive therapy (ECT) effectively ameliorate
symptoms in major depressive disorder (MDD). In rodents, both are associated with an …

The presence of adenosine in all nervous system cells (neurones and glia) together with its
intensive release following insults makes adenosine as a sort of 'regulator'of synaptic …

Adenosine is a neuromodulator mostly acting through A1 (inhibitory) and A2A (excitatory)
receptors in the brain. A2B receptors (A2 BR) are Gs/q‐protein‐coupled receptors with low …

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of
corticospinal tract motor neurons. Previous studies showed that adenosine-mediated …

A growing body of literature suggests that cannabis intake can induce memory loss in
humans and animals. Besides the recreational use, daily cannabis users may also belong to …

Beneficial effects of caffeine on memory processes have been observed in animal models
relevant to neurodegenerative diseases and aging, although the underlying mechanisms …

Adenosine is an endogenous purine nucleoside that regulates several physiological
functions, at the central and peripheral levels. Besides, adenosine has emerged as a major …