G protein coupled receptors (GPCRs) were first characterized as signal transducers that
elicit downstream effects through modulation of guanine (G) nucleotide-binding proteins …

Depression is a risk factor for both onset of cardiovascular disease (CVD) and increased
morbidity and mortality for those with CVD. Many, but not all studies, have found that …

Brain-derived neurotrophic factor (BDNF) is a member of the structurally and functionally
homologous neurotrophin family. It is the most widely distributed trophic factor in the brain …

Cognitive dysfunction syndrome (CDS) is a progressive neurodegenerative disorder of
senior dogs. Since age-related behavioural changes may be useful indicators for early …

Mapping of the human brain is more than the generation of an atlas-based parcellation of
brain regions using histologic or histochemical criteria. It is the attempt to provide a …

Depressive disorders are among the most frequent psychiatric diseases in the Western
world with prevalence numbers between 9% and 18%. They are characterized by …

The neurobiology of suicidal behaviour, which constitutes one of the most serious problems
both in psychiatry and general medical practice, still remains to a large degree unclear. As a …

Objective: To investigate the relationship between symptoms of depression and
cardiovascular reactivity during mental stress in patients with coronary artery disease (CAD) …

Cells, tissues and organs undergo phenotypic changes and deteriorate as they age. Cell
growth arrest and hyporesponsiveness to extrinsic stimuli are all hallmarks of senescent …

Background Brain α 2-and β-adrenoceptor alterations have been suggested in suicide and
major depressive disorder. Methods The densities of α 2-, β 1-and β 2-adrenoceptors in …