Valproic acid and epilepsy: from molecular mechanisms to clinical evidences
M Romoli, P Mazzocchetti, R D'Alonzo… - Current …, 2019 - ingentaconnect.com
After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …
Infections, inflammation and epilepsy
Epilepsy is the tendency to have unprovoked epileptic seizures. Anything causing structural
or functional derangement of brain physiology may lead to seizures, and different conditions …
or functional derangement of brain physiology may lead to seizures, and different conditions …
Animal models of seizures and epilepsy: past, present, and future role for the discovery of antiseizure drugs
W Löscher - Neurochemical research, 2017 - Springer
The identification of potential therapeutic agents for the treatment of epilepsy requires the
use of seizure models. Except for some early treatments, including bromides and …
use of seizure models. Except for some early treatments, including bromides and …
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …
Advances in the development of biomarkers for epilepsy
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs …
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs …
Hippocampal sclerosis in epilepsy: a neuropathology review
M Thom - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …
New avenues for anti-epileptic drug discovery and development
W Löscher, H Klitgaard, RE Twyman… - Nature reviews drug …, 2013 - nature.com
Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …
fail to control seizures in 20–30% of patients. However, our understanding of the …
[HTML][HTML] Pentylenetetrazole-induced kindling mouse model
T Shimada, K Yamagata - Journal of visualized experiments: JoVE, 2018 - ncbi.nlm.nih.gov
Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of
PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential …
PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential …
Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction
EM Goldberg, DA Coulter - Nature Reviews Neuroscience, 2013 - nature.com
Epilepsy is a prevalent neurological disorder associated with significant morbidity and
mortality, but the only available drug therapies target its symptoms rather than the underlying …
mortality, but the only available drug therapies target its symptoms rather than the underlying …
[HTML][HTML] Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
W Löscher - Seizure, 2011 - Elsevier
Animal models for seizures and epilepsy have played a fundamental role in advancing our
understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have …
understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have …