Purpose: Emerging published reports on the association between estrogen receptor 1
(ESR1) genetic variation and cancer susceptibility are inconsistent. This review and meta …

Background A growing body of literature suggests that migraineurs, particularly those with
aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The …

Estrogens are potent regulators of mature hematopoietic cells; however, their effects on
primitive and malignant hematopoietic cells remain unclear. Using genetic and …

Perinatal mood disorders, such as postpartum depression (PPD), are costly for society, with
potentially serious consequences for mother and child. While multiple genes appear to play …

Clinical reports show males have a higher bladder cancer (BCa) incidence than females.
The sexual difference of BCa occurrence suggests that estrogen and its receptors may affect …

Abstract Background and Aim The aim of this study is to explore the roles of estrogen
receptor (ER) subtypes and corresponding agonists/antagonists on the development of …

Once called “silent mutations” and assumed to have no effect on protein structure and
function, synonymous variants are now recognized to be drivers for some cancers. There …

Early studies documented the existence of sexual dimorphism in bladder cancer occurrence
and progression, with a greater bladder cancer incidence in males than females. However …

Evidence has accumulated that normal human and murine hematopoietic stem cells express
several functional pituitary and gonadal sex hormones, and that, in fact, some sex …

Obesity is associated with the increased incidence of colon cancer. Many cancer risk factors
have been identified including increased blood levels of insulin, leptin, interleukin-6 …