Stress constitutes a state of threatened homeostasis triggered by intrinsic or extrinsic
adverse forces (stressors) and is counteracted by an intricate repertoire of physiologic and …

Various environmental stressors, such as extreme temperatures (hot and cold), pathogens,
predators and insufficient food, can threaten life. Remarkable progress has recently been …

Abstract Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue: Function and
Physiological Significance. Physiol Rev 84: 277–359, 2004; 10.1152/physrev. 00015.2003 …

Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic
function of brown adipose tissue (BAT) and contributes to the maintenance of body …

▪ Abstract The stress response is subserved by the stress system, which is located both in
the central nervous system and the periphery. The principal effectors of the stress system …

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In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …

The hypothalamic-pituitary-adrenal axis exerts profound, multilevel inhibitory effects on the
female reproductive system. Corticotropin-releasing hormone (CRH) and CRH-induced …

The adipocyte-derived hormone leptin is a peripheral signal that informs the brain about the
metabolic status of an organism. Although traditionally viewed as an appetite-suppressing …

Our understanding of the physiological systems that regulate food intake and body weight
has increased immensely over the past decade. Brain centres, including the hypothalamus …