The pentose phosphate pathway in health and disease

T TeSlaa, M Ralser, J Fan, JD Rabinowitz - Nature metabolism, 2023 - nature.com
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

How neutrophils shape the immune response: reassessing their multifaceted role in health and disease

A Shafqat, JA Khan, AY Alkachem, H Sabur… - International Journal of …, 2023 - mdpi.com
Neutrophils are the most abundant of the circulating immune cells and are the first to be
recruited to sites of inflammation. Neutrophils are a heterogeneous group of immune cells …

Metabolic regulation of neutrophil functions in homeostasis and diseases

PO Leblanc, SG Bourgoin, PE Poubelle… - Journal of Leukocyte …, 2024 - academic.oup.com
Neutrophils are the most abundant leukocytes in humans and play a role in the innate
immune response by being the first cells attracted to the site of infection. While early studies …

Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study

MO El-Derany, DMF Hanna, J Youshia… - Pharmacological …, 2023 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded
as the twenty-first century's plague accounting for coronavirus disease 2019 (COVID-19) …

Crosstalk between neutrophil extracellular traps and immune regulation: insights into pathobiology and therapeutic implications of transfusion-related acute lung injury

Y Liu, R Wang, C Song, S Ding, Y Zuo, K Yi… - Frontiers in …, 2023 - frontiersin.org
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated
death, occurring during or within 6 hours after transfusion. Reports indicate that TRALI can …

The global role of G6PD in infection and immunity

SS Shah, EF Stone, RO Francis… - Frontiers in Immunology, 2024 - frontiersin.org
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy
in humans. G6PD is an essential enzyme in the pentose phosphate pathway (PPP) …

Metabolic predictors of COVID-19 mortality and severity: A Survival Analysis

AM Abdallah, A Doudin, TO Sulaiman, O Jamil… - Frontiers in …, 2024 - frontiersin.org
Introduction The global healthcare burden of COVID-19 pandemic has been unprecedented
with a high mortality. Metabolomics, a powerful technique, has been increasingly utilized to …

Not just sugar: metabolic control of neutrophil development and effector functions

P Ettel, T Weichhart - Journal of Leukocyte Biology, 2024 - academic.oup.com
The mammalian immune system is constantly surveying our tissues to clear pathogens and
maintain tissue homeostasis. In order to fulfill these tasks, immune cells take up nutrients to …

Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophils with activation across biological systems

R Datta, V Miskolci, GM Gallego Lopez, E Britt… - bioRxiv, 2024 - biorxiv.org
Neutrophils, the most abundant leukocytes in human peripheral circulation, are crucial for
the innate immune response. They are typically quiescent but rapidly activate in response to …

[HTML][HTML] High Serum S100A12 as a Diagnostic and Prognostic Biomarker for Severity, Multidrug-Resistant Bacteria Superinfection and Herpes Simplex Virus …

P Mester, D Keller, C Kunst, U Räth, S Rusch… - Viruses, 2024 - ncbi.nlm.nih.gov
Neutrophils are critical immune cells in severe coronavirus disease 2019 (COVID-19). S100
calcium-binding protein A12 (S100A12) is highly expressed in neutrophils during acute …