[HTML][HTML] Functions of N6-methyladenosine and its role in cancer

L He, H Li, A Wu, Y Peng, G Shu, G Yin - Molecular cancer, 2019 - Springer
Abstract N6-methyladenosine (m6A) is methylation that occurs in the N6-position of
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …

[HTML][HTML] The role of m6A modification in physiology and disease

C Yang, Y Hu, B Zhou, Y Bao, Z Li, C Gong… - Cell death & …, 2020 - nature.com
Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs
have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A) …

DirectRMDB: a database of post-transcriptional RNA modifications unveiled from direct RNA sequencing technology

Y Zhang, J Jiang, J Ma, Z Wei, Y Wang… - Nucleic Acids …, 2023 - academic.oup.com
With advanced technologies to map RNA modifications, our understanding of them has
been revolutionized, and they are seen to be far more widespread and important than …

[HTML][HTML] The RNA methyltransferase NSUN2 and its potential roles in cancer

A Chellamuthu, SG Gray - Cells, 2020 - mdpi.com
5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also
found increasingly in a plethora of RNA species, predominantly transfer RNAs, but …

The role of N6-methyladenosine mRNA in the tumor microenvironment

M Li, X Zha, S Wang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
In recent years, the most widely distributed eukaryotic messenger RNA (mRNA)
modification, N6-methyladenosine (m6A), has received a large amount of interest, in part …

N6-methyladenosine and neurological diseases

N Zhang, C Ding, Y Zuo, Y Peng, L Zuo - Molecular neurobiology, 2022 - Springer
Abstract N6-methyladenosine (m6A) is a dynamic reversible methylation modification of the
adenosine N6 position and is the most common chemical epigenetic modification among …

[HTML][HTML] The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes

X Zhang, X Li, H Jia, G An, J Ni - Journal of Biological Chemistry, 2021 - ASBMB
Mitochondrial biogenesis and energy metabolism are essential for regulating the
inflammatory state of monocytes. This state is partially controlled by peroxisome proliferator …

Tumor-Associated Macrophages Promote Oxaliplatin Resistance via METTL3-Mediated m6A of TRAF5 and Necroptosis in Colorectal Cancer

H Lan, Y Liu, J Liu, X Wang, Z Guan, J Du… - Molecular …, 2021 - ACS Publications
As a third-generation platinum drug, oxaliplatin (OX) is widely used as the first-line
chemotherapeutic agent in the treatment of colorectal cancer (CRC). CRC cells acquire …

Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila

L Worpenberg, C Paolantoni, S Longhi… - The EMBO …, 2021 - embopress.org
Abstract N6‐methyladenosine (m6A) regulates a variety of physiological processes through
modulation of RNA metabolism. This modification is particularly enriched in the nervous …

[HTML][HTML] The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling

Y Zhao, Y Chen, M Jin, J Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Epigenetic regulation involves a range of sophisticated processes which contribute to
heritable alterations in gene expression without altering DNA sequence. Regulatory events …