Numerous treatments have been reported to provide a beneficial outcome in experimental
animal stroke models; however, these treatments (with the exception of tissue plasminogen …

Inflammation is a classical host defence response to infection and injury that has many
beneficial effects. However, inappropriate (in time, place and magnitude) inflammation is …

Ischemic stroke not only impairs neuronal function but also affects the cerebral vasculature
as indicated by loss of blood—brain barrier (BBB) integrity. Therefore, therapeutical …

Throughout the history of research on stroke pathophysiology, focus has shifted from purely
vascular concepts to the insight that a complex interplay of biochemical and molecular …

Despite years of basic research and pioneering clinical work, ischemic stroke remains a
major public health concern. Prior STAIR (Stroke Treatment Academic Industry Roundtable) …

Chronic systemic inflammatory conditions, such as atherosclerosis, diabetes and obesity are
associated with increased risk of stroke, which suggests that systemic inflammation may …

Endogenous defence mechanisms by which the brain protects itself against noxious stimuli
and recovers from ischaemic damage are a key target of stroke research. The loss of viable …

Dirnagl and Endres Found in Translation 1511 has failed to deliver evidence for a clinical
benefit of any of the neuroprotectants tested. Recent examples include erythropoietin, 18 …

The term blood-brain barrier (BBB) relates to the ability of cerebral vessels to hold back
hydrophilic and large molecules from entering the brain, thereby crucially contributing to …

Many promising findings from pre-clinical research have failed to translate to the clinic due
to their inability to incorporate human disease co-morbidity. A variety of rodent diets and …