The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism

BJ Willett, J Grove, OA MacLean, C Wilkie, N Logan… - MedRxiv, 2022 - medrxiv.org
Vaccination-based exposure to spike protein derived from early SARS-CoV-2 sequences is
the key public health strategy against COVID-19. Successive waves of SARS-CoV-2 …

[PDF][PDF] Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

V Servellita, AM Syed, MK Morris, N Brazer, P Saldhi… - Cell, 2022 - cell.com
Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity
against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated …

[HTML][HTML] A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

M Kumari, RM Lu, MC Li, JL Huang, FF Hsu… - Journal of biomedical …, 2022 - Springer
The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis,
presenting a broad range of challenges. To help address some of the main problems, the …

[PDF][PDF] Circular RNA vaccines against SARS-CoV-2 and emerging variants

L Qu, Z Yi, Y Shen, L Lin, F Chen, Y Xu, Z Wu, H Tang… - Cell, 2022 - cell.com
As the emerging variants of SARS-CoV-2 continue to drive the worldwide pandemic, there is
a constant demand for vaccines that offer more effective and broad-spectrum protection …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies

X Wang, X Zhao, J Song, J Wu, Y Zhu, M Li… - Emerging microbes & …, 2022 - Taylor & Francis
The massive and rapid transmission of SARS-CoV-2 has led to the emergence of several
viral variants of concern (VOCs), with the most recent one, B. 1.1. 529 (Omicron), which …

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody

W Yin, Y Xu, P Xu, X Cao, C Wu, C Gu, X He, X Wang… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has
become the dominant infective strain. We report the structures of the Omicron spike trimer on …

[HTML][HTML] A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination

G Zhang, Y Cong, FL Liu, J Sun, J Zhang, G Cao… - Nature …, 2022 - nature.com
The global emergency caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and …

Omicron BA. 2 breakthrough infection enhances cross-neutralization of BA. 2.12. 1 and BA. 4/BA. 5

A Muik, BG Lui, M Bacher, AK Wallisch, A Toker… - Science …, 2022 - science.org
BNT162b2-vaccinated individuals after Omicron BA. 1 breakthrough infection have strong
serum-neutralizing activity against Omicron BA. 1, BA. 2, and previous SARS-CoV-2 variants …