Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA. 1 and BA. 2

B Hu, JFW Chan, H Liu, Y Liu, Y Chai… - Emerging Microbes & …, 2022 - Taylor & Francis
ABSTRACT SARS-CoV-2 B. 1.1. 529.1 (Omicron BA. 1) emerged in November 2021 and
quickly became the predominant circulating SARS-CoV-2 variant globally. Omicron BA. 1 …

Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants

B Ju, Q Zhang, Z Wang, ZQ Aw, P Chen, B Zhou… - Nature …, 2023 - nature.com
The omicron variants of SARS-CoV-2 have substantial ability to escape infection-and
vaccine-elicited antibody immunity. Here, we investigated the extent of such escape in nine …

An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion

S Luo, J Zhang, AJB Kreutzberger, A Eaton… - Science …, 2022 - science.org
SARS-CoV-2 Omicron subvariants have generated a worldwide health crisis due to
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …

Omicron infection enhances Delta antibody immunity in vaccinated persons

K Khan, F Karim, S Cele, K Reedoy, JE San, G Lustig… - Nature, 2022 - nature.com
The extent to which Omicron infection,,,,,,,–, with or without previous vaccination, elicits
protection against the previously dominant Delta (B. 1.617. 2) variant is unclear. Here we …

SARS‐CoV‐2 Omicron variant: Immune escape and vaccine development

D Ao, T Lan, X He, J Liu, L Chen, DT Baptista‐Hon… - MedComm, 2022 - Wiley Online Library
New genetic variants of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
constantly emerge through unmitigated spread of the virus in the ongoing Coronavirus …

A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant

C He, J Yang, W Hong, Z Chen, D Peng, H Lei… - Nature …, 2022 - nature.com
The recently emerged Omicron (B. 1.1. 529) variant has rapidly surpassed Delta to become
the predominant circulating SARS-CoV-2 variant, given the higher transmissibility rate and …

Current and emerging knowledge in COVID-19

YJ Jeong, YM Wi, H Park, JE Lee, SH Kim, KS Lee - Radiology, 2023 - pubs.rsna.org
COVID-19 has emerged as a pandemic leading to a global public health crisis of
unprecedented morbidity. A comprehensive insight into the imaging of COVID-19 has …

High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

A Alemany, P Millat-Martinez… - The Lancet …, 2022 - thelancet.com
Background Convalescent plasma has been proposed as an early treatment to interrupt the
progression of early COVID-19 to severe disease, but there is little definitive evidence. We …

[PDF][PDF] Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice

B Ying, SM Scheaffer, B Whitener, CY Liang… - Cell, 2022 - cell.com
The large number of spike substitutions in Omicron lineage variants (BA. 1, BA. 1.1., and BA.
2) could jeopardize the efficacy of SARS-CoV-2 vaccines. We evaluated in mice the …

S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters

M Sasaki, K Tabata, M Kishimoto, Y Itakura… - Science translational …, 2022 - science.org
In parallel with vaccination, oral antiviral agents are highly anticipated to act as
countermeasures for the treatment of the coronavirus disease 2019 (COVID-19) pandemic …