Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies

TH Pham, AM Gardier - Pharmacology & therapeutics, 2019 - Elsevier
Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …

5‐hydroxytryptamine in migraine: The puzzling role of ionotropic 5‐HT3 receptor in the context of established therapeutic effect of metabotropic 5‐HT1 subtypes

R Giniatullin - British Journal of Pharmacology, 2022 - Wiley Online Library
5‐hydroxytryptamine (5‐HT; serotonin) is traditionally considered as a key mediator
implicated in migraine. Multiple 5‐HT receptor subtypes contribute to a variety of region …

Human lesions and animal studies link the claustrum to perception, salience, sleep and pain

H Atilgan, M Doody, DK Oliver, TM McGrath… - Brain, 2022 - academic.oup.com
The claustrum is the most densely interconnected region in the human brain. Despite the
accumulating data from clinical and experimental studies, the functional role of the claustrum …

[HTML][HTML] Effects of subchronic administrations of vortioxetine, lurasidone, and escitalopram on thalamocortical glutamatergic transmission associated with serotonin 5 …

M Okada, R Matsumoto, Y Yamamoto… - International Journal of …, 2021 - mdpi.com
The functional suppression of serotonin (5-HT) type 7 receptor (5-HT7R) is forming a basis
for scientific discussion in psychopharmacology due to its rapid-acting antidepressant-like …

[HTML][HTML] 5-HT receptors and temperature homeostasis

IP Voronova - Biomolecules, 2021 - mdpi.com
The present review summarizes the data concerning the influence of serotonin (5-HT)
receptors on body temperature in warm-blooded animals and on processes associated with …

Dexmedetomidine alleviates pain in MPTP-treated mice by activating the AMPK/mTOR/NF-κB pathways in astrocytes

Y Chen, Y Li, C Li, D Zhu, O Cheng, J Cui - Neuroscience Letters, 2022 - Elsevier
Pain is a major non-motor symptom that contributes to impaired quality of life in Parkinson's
disease (PD). However, the mechanisms and treatment of pain in PD have not been well …

[HTML][HTML] Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent

Y Kobayashi, R Imamura, Y Koyama, M Kondo… - Scientific Reports, 2020 - nature.com
We have developed Si-based agent which can generate a large amount of hydrogen. Si-
based agent continues generating hydrogen for more than 24 h by the reaction with water …

Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling …

A Rezayof, Z Ghasemzadeh, OH Sahafi - Neurochemistry International, 2023 - Elsevier
Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …

[HTML][HTML] The claustrum and consciousness: An update

YS Liaw, GJ Augustine - International Journal of Clinical and Health …, 2023 - Elsevier
The seminal paper of Crick and Koch (2005) proposed that the claustrum, an enigmatic and
thin grey matter structure that lies beside the insular cortex, may be involved in the …

Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy‐induced neuropathy: the role of spinal 5‐HT3 receptors

JT Costa‐Pereira, P Serrão, I Martins… - European Journal of …, 2020 - Wiley Online Library
Chemotherapy‐induced neuropathy (CIN) is a common complication of cancer treatment.
Although CIN is treated with antidepressants that act at serotonin (5‐HT) reuptake, the …