Metabolic regulation plays important roles in embryo development and uterine receptivity
during early pregnancy, ultimately influencing pregnancy efficiency in mammals. The …

Pregnancy establishment in mammals, including pigs, requires coordinated communication
between developing conceptuses (embryos with associated membranes) and the maternal …

Conceptus estrogens and prostaglandins have long been considered the primary signals for
maternal recognition of pregnancy (MRP) in the pig. However, loss-of-function studies …

Aims Prostaglandins are important signaling lipids with prostaglandin E 2 (PGE 2) known to
be the most abundant prostaglandin across tissues. In kidney, PGE 2 plays an important role …

Development of viviparity in mammals requires that the placenta evolves as an intermediate
interface between the fetus and maternal uterus. In addition to the retention of the fetus and …

Scope Uterine receptivity is a major restriction of embryo implantation and survival, and the
endometrial luminal epithelium serves as the transient gateway for uterine receptivity and …

Abstract Prokineticin 1 (PROK1) is an important factor in pregnancy establishment in pigs,
acting at the embryo–maternal interface and the corpus luteum (CL). Estradiol-17β (E2) is …

Maternal recognition of pregnancy (MRP) is a term utilized in mammals to describe
pathways in which the conceptus alters the endometrial environment to prevent regression …

During early pregnancy, porcine conceptuses (the embryos with associated membranes)
secrete estradiol-17β (E2)—their major signal for maternal recognition of pregnancy—and …

Albuminuria represents a hallmark of both early kidney injury and chronic kidney disease
(CKD). The importance of albuminuria as a prognosis marker is demonstrated by recent …