Bisindole natural products: A vital source for the development of new anticancer drugs
M Xu, R Peng, Q Min, S Hui, X Chen, G Yang… - European Journal of …, 2022 - Elsevier
Currently, the number of new cancer cases and deaths worldwide is increasing year on
year. In addition to the requirement for cancer prevention, the top priority is still to seek the …
year. In addition to the requirement for cancer prevention, the top priority is still to seek the …
[HTML][HTML] Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets
R Qin, FM You, Q Zhao, X Xie, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …
signal transduction pathways and can be regulated by genetic signals or drug interventions …
Indole alkaloids from marine resources: Understandings from therapeutic point of view to treat cancers
F Islam, Z Dehbia, M Zehravi, R Das… - Chemico-Biological …, 2023 - Elsevier
Cancer is the leading cause of mortality all over the world. Scientific investigation has
demonstrated that disruptions in the process of autophagy are frequently interrelated with …
demonstrated that disruptions in the process of autophagy are frequently interrelated with …
Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities
Two new chlorinated bis-indole alkaloids, dionemycin (1) and 6-OMe-7′, 7 ″-
dichorochromopyrrolic acid (2), along with seven known analogs 3–9, were isolated from the …
dichorochromopyrrolic acid (2), along with seven known analogs 3–9, were isolated from the …
Unburned tobacco cigarette smoke alters rat ultrastructural lung airways and DNA
Abstract Introduction Recently, the Food and Drug Administration authorized the marketing
of IQOS Tobacco Heating System as a Modified Risk Tobacco Product based on an …
of IQOS Tobacco Heating System as a Modified Risk Tobacco Product based on an …
[HTML][HTML] Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development
M Xu, Z Bai, B Xie, R Peng, Z Du, Y Liu, G Zhang… - Molecules, 2024 - mdpi.com
Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through
multiple mechanisms. Comprehensive research has shown that the development success …
multiple mechanisms. Comprehensive research has shown that the development success …
[HTML][HTML] Marine alkaloid 2, 2-bis (6-bromo-3-indolyl) ethylamine and its synthetic derivatives inhibit microbial biofilms formation and disaggregate developed biofilms
The antimicrobial activity of the marine bisindole alkaloid 2, 2-bis (6-bromo-3-indolyl)
ethylamine (1) and related synthetic analogues (compounds 2–8) against target …
ethylamine (1) and related synthetic analogues (compounds 2–8) against target …
Quantification of 2-and 3-isopropylmalic acids in forty Italian wines by UHPLC-MS/MS triple quadrupole and evaluation of their antimicrobial, antioxidant activities and …
Isopropylmalic acid (2-IPMA) and 3-isopropylmalic acid (3-IPMA), recently discovered in
wines, were simultaneously quantified in forty wines by UHPLC-MS/MS triple quadrupole …
wines, were simultaneously quantified in forty wines by UHPLC-MS/MS triple quadrupole …
Phenotype screening of an azole-bisindole chemical library identifies URB1483 as a new antileishmanial agent devoid of toxicity on human cells
We report the evaluation of a small library of azole-bisindoles for their antileishmanial
potential, in terms of efficacy on Leishmania infantum promastigotes and intracellular …
potential, in terms of efficacy on Leishmania infantum promastigotes and intracellular …
Dehydrogenation and α-functionalization of secondary amines by visible-light-mediated catalysis
F Stanek, R Pawlowski, P Morawska, R Bujok… - Organic & …, 2020 - pubs.rsc.org
A visible-light-mediated process for dehydrogenation of amines has been described. The
given protocol showed a broad substrate scope, mild reaction conditions and excellent …
given protocol showed a broad substrate scope, mild reaction conditions and excellent …