Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …

Increasing evidence suggests that Zn2+ acts as a second messenger capable of
transducing extracellular stimuli into intracellular signaling events. The importance of Zn2+ …

Aberrant Zn 2+ homeostasis is a hallmark of certain cardiomyopathies associated with
altered contractile force. In this study, we addressed whether Zn 2+ modulates cardiac …

The skeletal muscle ryanodine receptor isoform 1 (RyR1) is a calcium release channel
involved in excitation–contraction coupling, the process whereby an action potential is …

The sarcoplasmic reticulum (SR) in cardiac muscle is suggested to act as a dynamic storage
for Zn2+ release and reuptake, albeit it is primarily implicated in the Ca2+ signaling required …

The synergic effect of luminal Ca2+, cytosolic Ca2+, and cytosolic adenosine triphosphate
(ATP) on activation of cardiac ryanodine receptor (RYR2) channels was examined in planar …

Coupled gating (synchronous openings and closures) of groups of skeletal muscle
ryanodine receptors (RyR1), which mimics RyR1-mediated Ca2+ release underlying Ca2+ …

It is well established that mammalian cells contain a small but measurable pool of free or
labile zinc in the cytosol that is buffered in the high picomolar range. Recent attention has …

The role of cardiac ryanodine receptor (RyR) gating in the initiation and propagation of
calcium waves was investigated using a mathematical model comprising a stochastic …

K201 (JTV-519) may prevent abnormal Ca2+ leak from the sarcoplasmic reticulum (SR) in
the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; …