Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Epithelial-mesenchymal transition (EMT) is described as the process in which injured renal
tubular epithelial cells undergo a phenotype change, acquiring mesenchymal characteristics …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Mesenchymal stem cells-derived exosomes (MSC-exos) have attracted great interest as a
cell-free therapy for acute kidney injury (AKI). However, the in vivo biodistribution of MSC …

Background Exosomes derived from mesenchymal stem cells (MSC-exos) have been
demonstrated with great potential in the treatment of multiple human diseases including …

Following acute kidney injury (AKI), renal tubular cells may stimulate fibroblasts in a
paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation …

Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC-EVs) have been
recognized as a promising cell-free therapy for acute kidney injury (AKI), which avoids safety …

Renal fibrosis is a common pathological process that occurs with diverse etiologies in
chronic kidney disease. However, its regulatory mechanisms have not yet been fully …

Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …

Acute kidney injury (AKI) is a common clinical state resulting from pathogenic conditions
such as ischemic and toxic insults. The pathophysiology of AKI shares common pathogenic …