Human organs-on-chips for disease modelling, drug development and personalized medicine
DE Ingber - Nature Reviews Genetics, 2022 - nature.com
The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …
[HTML][HTML] Why 90% of clinical drug development fails and how to improve it?
Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …
strategies, which raised the question whether certain aspects in target validation and drug …
Organ-on-a-chip: a new paradigm for drug development
The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …
[HTML][HTML] 3D printing of hydrogels: Rational design strategies and emerging biomedical applications
Abstract 3D printing alias additive manufacturing can transform 3D virtual models created by
computer-aided design (CAD) into physical 3D objects in a layer-by-layer manner …
computer-aided design (CAD) into physical 3D objects in a layer-by-layer manner …
Digital twin: Values, challenges and enablers from a modeling perspective
Digital twin can be defined as a virtual representation of a physical asset enabled through
data and simulators for real-time prediction, optimization, monitoring, controlling, and …
data and simulators for real-time prediction, optimization, monitoring, controlling, and …
Host–microbiota maladaptation in colorectal cancer
A Janney, F Powrie, EH Mann - Nature, 2020 - nature.com
Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …
characterized by the accumulation of mutations and a dysregulated immune response. Up to …
Advanced soft materials, sensor integrations, and applications of wearable flexible hybrid electronics in healthcare, energy, and environment
Recent advances in soft materials and system integration technologies have provided a
unique opportunity to design various types of wearable flexible hybrid electronics (WFHE) …
unique opportunity to design various types of wearable flexible hybrid electronics (WFHE) …
3D bioprinting for reconstituting the cancer microenvironment
The cancer microenvironment is known for its complexity, both in its content as well as its
dynamic nature, which is difficult to study using two-dimensional (2D) cell culture models …
dynamic nature, which is difficult to study using two-dimensional (2D) cell culture models …
Tumor-on-a-chip: from bioinspired design to biomedical application
X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …
cancer biology and develop anticancer therapies. The main challenges in cancer research …