Clinical significance of microRNAs in chronic and acute human leukemia

CH Yeh, R Moles, C Nicot - Molecular cancer, 2016 - Springer
Small non-coding microRNAs (miRNAs) are epigenetic regulators that target specific cellular
mRNA to modulate gene expression patterns and cellular signaling pathways. miRNAs are …

Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

HTLV-1 infection and pathogenesis: new insights from cellular and animal models

G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal
models have provided invaluable contributions in the knowledge of viral infection …

Overview of biological mechanisms of human carcinogens

N Birkett, M Al-Zoughool, M Bird, RA Baan… - Journal of Toxicology …, 2019 - Taylor & Francis
This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens
identified as causes of human cancer through Volume 106 of the IARC Monographs. The …

The role of microRNAs in the viral infections

M Fani, M Zandi, M Rezayi, N Khodadad… - Current …, 2018 - ingentaconnect.com
MicroRNAs (miRNAs) are non-coding RNAs with 19 to 24 nucleotides which are
evolutionally conserved. MicroRNAs play a regulatory role in many cellular functions such …

Potential miRNA-gene interactions determining progression of various ATLL cancer subtypes after infection by HTLV-1 oncovirus

MZ Ghobadi, E Afsaneh, R Emamzadeh… - BMC Medical …, 2023 - Springer
Abstract Background Adult T-cell Leukemia/Lymphoma (ATLL) is a rapidly progressing type
of T-cell non-Hodgkin lymphoma that is developed after the infection by human T-cell …

Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia

M Bellon, L Lu, C Nicot - Blood, The Journal of the American …, 2016 - ashpublications.org
Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia | Blood |
American Society of Hematology Skip to Main Content Advertisement Umbrella Alt Text …

MicroRNAs-based therapy: a novel and promising strategy for cancer treatment.

R Moles - MicroRNA (Shariqah, United Arab Emirates), 2017 - europepmc.org
MicroRNAs are short non-coding RNAs involved in critical biological processes. In the past
decade, the deregulation of miRNAs has been well-documented in a wide range of human …

Oncogenic viruses-encoded microRNAs and their role in the progression of cancer: Emerging targets for antiviral and anticancer therapies

M Kandeel - Pharmaceuticals, 2023 - mdpi.com
Approximately 20% of all cases of human cancer are caused by viral infections. Although a
great number of viruses are capable of causing a wide range of tumors in animals, only …

Deciphering microRNA-mRNA regulatory network in adult T-cell leukemia/lymphoma; the battle between oncogenes and anti-oncogenes

MZ Ghobadi, R Emamzadeh, SH Mozhgani - Plos one, 2021 - journals.plos.org
Adult T-cell leukemia/lymphoma (ATLL) is virus-caused cancer that originates from the
infection by human T-cell leukemia virus type 1. ATLL dysregulates various biological …