The medical uses of gold have a long history; rheumatoid arthritis is currently treated with
gold-based drugs and there is increasing interest in the application of gold complexes as …

Chagas disease affects 7.7 million people and 28 million people are at risk of acquiring the
disease in 15 endemic countries of Latin America. Benznidazole and nifurtimox are drugs …

One major goal of research on Chagas disease is the development of effective
chemotherapy to eliminate the infection from individuals who have not yet developed …

Trypanosoma cruzi infection triggers substantial production of nitric oxide (NO), which has
been shown to have protective and toxic effects on the host's immune system. Sensing of …

This study was designed to verify the in vivo efficacy of sulfoxide and sulfone fexinidazole
metabolites following oral administration in a murine model of Chagas disease. Female …

The nitroheterocyclic drugs nifurtimox and benznidazole are first-line drugs available to treat
Chagas disease; however, they have limitations, including long treatment courses and …

Background The protozoan Trypanosoma cruzi is the causative agent of Chagas disease.
There are no vaccines or effective treatment, especially in the chronic phase when most …

The etiological treatment of Chagas disease is recommended for all patients with acute or
recent chronic infection, but controversies remain regarding the benefit of chemotherapy and …

Chagas disease is endemic and is recognized as a major health problem in many Latin
American countries. Despite the parallels between socio-economic and environmental …

ABSTRACT High-throughput screening of 100,000 lead-like compounds led to the
identification of nine novel chemical classes of trypanothione reductase (TR) inhibitors …