5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

Addiction, the most severe form of substance use disorder, is a chronic brain disorder
molded by strong biosocial factors that has devastating consequences to individuals and to …

Adolescence is a developmental period when physical and cognitive abilities are optimized,
when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal …

The specific role of serotonin and its interplay with dopamine (DA) in adaptive, reward
guided behavior as well as drug dependance, still remains elusive. Recently, novel methods …

Compulsive behaviors are driven by repetitive urges and typically involve the experience of
limited voluntary control over these urges, a diminished ability to delay or inhibit these …

Compulsive drug use despite adverse consequences defines addiction. While mesolimbic
dopamine signaling is sufficient to drive compulsion, psychostimulants such as cocaine also …

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

Cigarette smoking is often initiated during adolescence and an earlier age of onset is
associated with worse health outcomes later in life. Paradoxically, the transition towards …