[HTML][HTML] Unnatural helical peptidic foldamers as protein segment mimics

P Sang, J Cai - Chemical Society Reviews, 2023 - pubs.rsc.org
Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

[HTML][HTML] Congenital hyperinsulinism in infancy and childhood: challenges, unmet needs and the perspective of patients and families

I Banerjee, J Raskin, JB Arnoux, DD De Leon… - Orphanet journal of rare …, 2022 - Springer
Background Congenital hyperinsulinism (CHI) is the most common cause of persistent
hypoglycemia in infants and children, and carries a considerable risk of neurological …

[HTML][HTML] Impact of glucose metabolism on the developing brain

M Cacciatore, EA Grasso, R Tripodi… - Frontiers in …, 2022 - frontiersin.org
Glucose is the most important substrate for proper brain functioning and development, with
an increased glucose consumption in relation to the need of creating new brain structures …

[HTML][HTML] Standardised practices in the networked management of congenital hyperinsulinism: a UK national collaborative consensus

MG Shaikh, AK Lucas-Herald, A Dastamani… - Frontiers in …, 2023 - frontiersin.org
Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent
hypoglycaemia in infants and young children caused by inappropriate insulin over …

[HTML][HTML] The hypoglycaemia error grid: A UK-wide consensus on CGM accuracy assessment in hyperinsulinism

C Worth, MJ Dunne, M Salomon-Estebanez… - Frontiers in …, 2022 - frontiersin.org
Objective Continuous Glucose Monitoring (CGM) is gaining in popularity for patients with
paediatric hypoglycaemia disorders such as Congenital Hyperinsulinism (CHI), but no …

[HTML][HTML] KATP channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapies

A ElSheikh, SL Shyng - Frontiers in Endocrinology, 2023 - frontiersin.org
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in
infancy/childhood and is a serious condition associated with severe recurrent attacks of …

Continuous glucose monitoring in the management of neonates with persistent hypoglycemia and congenital hyperinsulinism

M Win, R Beckett, L Thomson… - The Journal of …, 2022 - academic.oup.com
Background Persistent hypoglycemia is common in the newborn and is associated with poor
neurodevelopmental outcome. Adequate monitoring is critical in prevention, but is …

[HTML][HTML] SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism

V Lithovius, J Saarimäki-Vire, D Balboa, H Ibrahim… - Diabetologia, 2021 - Springer
Aims/hypothesis Congenital hyperinsulinism caused by mutations in the K ATP-channel-
encoding genes (K ATP HI) is a potentially life-threatening disorder of the pancreatic beta …

[HTML][HTML] Using referral rates for genetic testing to determine the incidence of a rare disease: the minimal incidence of congenital hyperinsulinism in the UK is 1 in …

D Yau, TW Laver, A Dastamani, S Senniappan… - PLoS …, 2020 - journals.plos.org
Congenital hyperinsulinism (CHI) is a significant cause of hypoglycaemia in neonates and
infants with the potential for permanent neurologic injury. Accurate calculations of the …

Long-term outcome and treatment in persistent and transient congenital hyperinsulinism: a Finnish population-based study

JME Männistö, J Jääskeläinen… - The Journal of …, 2021 - academic.oup.com
Context The management of congenital hyperinsulinism (CHI) has improved. Objective To
examine the treatment and long-term outcome of Finnish patients with persistent and …