On the origin of ATP synthesis in cancer
TN Seyfried, G Arismendi-Morillo, P Mukherjee… - Iscience, 2020 - cell.com
ATP is required for mammalian cells to remain viable and to perform genetically
programmed functions. Maintenance of the ΔG′ ATP hydrolysis of− 56 kJ/mole is the …
programmed functions. Maintenance of the ΔG′ ATP hydrolysis of− 56 kJ/mole is the …
Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation
RJ Klement - Medical Oncology, 2017 - Springer
Ketogenic diets (KDs) have gained popularity among patients and researchers alike due to
their putative anti-tumor mechanisms. However, the question remains which conclusions …
their putative anti-tumor mechanisms. However, the question remains which conclusions …
Effects of Ketogenic metabolic therapy on patients with breast cancer: A randomized controlled clinical trial
A Khodabakhshi, ME Akbari, HR Mirzaei, TN Seyfried… - Clinical Nutrition, 2021 - Elsevier
Background Ketogenic metabolic therapy (KMT) using ketogenic diets (KD) is emerging as
viable alternative or complementary strategy for managing cancer; however, few clinical …
viable alternative or complementary strategy for managing cancer; however, few clinical …
Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming
S Hirschberger, G Strauß, D Effinger… - EMBO Molecular …, 2021 - embopress.org
Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as
alternative energy substrates. There are as yet unproven assumptions that ketone bodies …
alternative energy substrates. There are as yet unproven assumptions that ketone bodies …
Could ketogenic diet “starve” cancer? Emerging evidence
Cancer cells (CCs) predominantly use aerobic glycolysis (Warburg effect) for their
metabolism. This important characteristic of CCs represents a potential metabolic pathway to …
metabolism. This important characteristic of CCs represents a potential metabolic pathway to …
Mitochondrial substrate-level phosphorylation as energy source for glioblastoma: review and hypothesis
C Chinopoulos, TN Seyfried - ASN neuro, 2018 - journals.sagepub.com
Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain
cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit …
cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit …
Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma
P Mukherjee, ZM Augur, M Li, C Hill… - Communications …, 2019 - nature.com
Glioblastoma (GBM) is an aggressive primary human brain tumour that has resisted effective
therapy for decades. Although glucose and glutamine are the major fuels that drive GBM …
therapy for decades. Although glucose and glutamine are the major fuels that drive GBM …
The emerging role of ketogenic diets in cancer treatment
RJ Klement - Current Opinion in Clinical Nutrition & Metabolic …, 2019 - journals.lww.com
Ketogenic diets against cancer are worth further exploration, both in the laboratory and
clinically. Patients wishing to undertake a ketogenic diet during therapy should receive …
clinically. Patients wishing to undertake a ketogenic diet during therapy should receive …
[HTML][HTML] Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle
Background Aberrant metabolism is recognized as a hallmark of cancer, a pillar necessary
for cellular proliferation. Regarding bioenergetics (ATP generation), most cancers display a …
for cellular proliferation. Regarding bioenergetics (ATP generation), most cancers display a …
A systematic review of the use of ketogenic diets in adult patients with cancer
J Sremanakova, AM Sowerbutts… - Journal of human …, 2018 - Wiley Online Library
Background A growing body of evidence indicates the importance of nutrition in cancer
treatment. Ketogenic diets are one strategy that has been proposed to enhance traditional …
treatment. Ketogenic diets are one strategy that has been proposed to enhance traditional …