The Golgi apparatus is a highly dynamic organelle through which nascent proteins released
from the endoplasmic reticulum (ER) are trafficked. Proteins are post-translationally modified …

The density and composition of cell surface proteins are major determinants for cellular
functions. Regulation of cell surface molecules occurs at several levels, including the …

Amphiphysins are BIN-amphiphysin-RVS (BAR) domain-containing proteins that influence
membrane curvature in sites such as T-tubules in muscular cells, endocytic pits in neuronal …

The microtubule cytoskeleton is crucial for the intracellular organization of eukaryotic cells. It
is a dynamic scaffold that has to perform a variety of very different functions. This …

The intimate link between microtubule (MT) organization and the components of the
secretory pathway has suggested that MT-based motility is an essential component of …

Alterations in endoplasmic reticulum (ER) cholesterol are fundamental for a variety of
cellular processes such as the regulation of lipid homeostasis or efficient protein …

Background The transport of endoplasmic reticulum (ER)-derived COPII vesicles toward the
ER-Golgi intermediate compartment (ERGIC) requires cytoplasmic dynein and is dependent …

Golgi fragmentation is an early hallmark of many neurodegenerative diseases but its
pathophysiological relevance and molecular mechanisms are unclear. We here …

Fusion of Golgi-derived COP (coat protein)-I vesicles with the endoplasmic reticulum (ER) is
initiated by specific tethering complexes: the Dsl1 (depends on SLY1-20) complex in yeast …

Nutrient transporters, being polytopic membrane proteins, are believed, but not formally
shown, to traffic from their site of synthesis, the ER, to the plasma membrane through Golgi …