Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

The zebrafish (D anio rerio) is a freshwater teleost of the family C yprinidae that is
established as a model organism in many research fields. Here, we define the …

methylcytosine is a major epigenetic modification that is sometimes called" the fifth
nucleotide." However, our knowledge of how offspring inherit the DNA methylome from …

Early vertebrate embryos must achieve totipotency and prepare for zygotic genome
activation (ZGA). To understand this process, we determined the DNA methylation (DNAme) …

Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms
and enzymes remain unclear. Using zebrafish embryos we provide evidence for 5 …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Endocrine-disrupting compounds (EDCs) are widespread in the aquatic environment and
can cause alterations in development, physiological homeostasis and health of vertebrates …

Background: Chlorinated phosphate esters (CPEs) are widely used as additive flame
retardants for low-density polyurethane foams and have frequently been detected at …

In mature human sperm, genes of importance for embryo development (ie, transcription
factors) lack DNA methylation and bear nucleosomes with distinctive histone modifications …

Endocrine disruptors (EDs) interfere with different hormonal and metabolic processes and
disrupt the development of organs and tissues, as well as the reproductive system. In …