As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity
and substantial population structure. Importantly, African genomes are heterogeneous: They …

Genomics can reveal essential features about the demographic evolution of a population
that may not be apparent from historical elements. In recent years, there has been a …

Inborn errors of immunity (IEI) are genetic disorders with extensive clinical presentations.
They can range from increased susceptibility to infections to significant immune …

Peoples speaking so-called Khoisan languages—that is, indigenous languages of southern
Africa that do not belong to the Bantu family—are culturally and linguistically diverse. They …

We previously proposed a structure for recording consent-based data use 'categories' and
'requirements'–Consent Codes–with a view to supporting maximum use and integration of …

Background Recombination maps are important resources for epidemiological and
evolutionary analyses; however, there are currently no recombination maps representing …

Abstract The International Tuberculosis Host Genetics Consortium (ITHGC) demonstrated
the power of large-scale GWAS analysis across diverse ancestries in identifying tuberculosis …

Recombination maps are important resources for epidemiological and evolutionary
analyses, however, there are currently no recombination maps representing any African …

Rare diseases (RDs) may individually be rare, but cumulatively affect up to 6% of the
population. In Africa, research and diagnostics for RDs have not been prioritised. Therefore …