The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities
that result in neurohormonal activation and autonomic imbalance with increase in …

Heart failure (HF) is a complex clinical syndrome characterized by the activation of at least
several neurohumoral pathways that have a common role in maintaining cardiac output and …

G protein-coupled receptors (GPCRs) transmit information to the cell interior by transducing
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …

Context Mirabegron, the first β 3-adrenoceptor agonist in clinical practice, is approved for
treatment of overactive bladder (OAB) syndrome symptoms. Because β 3-adrenoceptors are …

Aims To quantify acute energy expenditure, supraclavicular skin temperature and
cardiovascular responses to four doses of the β3‐adrenoceptor agonist, mirabegron …

G protein-coupled receptors (GPCRs) play a key role in cellular communication, allowing
human cells to sense external cues or to talk each other through hormones or …

Purpose: The bladder effects of isoprenaline, and selective β1 and β2-adrenoceptor
agonists reported in early studies suggest that bladder β-adrenoceptors are atypical. Since …

Heterotrimeric guanine nucleotide-binding proteins (G proteins) deliver external signals to
the cell interior, upon activation by the external signal stimulated G protein-coupled …

Beta3-adrenoreceptors (B3AR) are traditionally known as metabolic receptors in adipose
tissue, but came into focus in the cardiovascular field after our demonstration of their …

The β 3-adrenergic receptor (β 3-AR) is an important regulator of various physiological
functions, such as thermogenesis in brown adipose tissue, lipolysis in white adipose tissue …