Acute liver injury (ALI) is a globally important public health issue that, when severe, rapidly
progresses to acute liver failure, seriously compromising the life safety of patients. The …

Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital
functions across diverse cellular processes. Dysfunctions within mitochondria serve as …

Acetaminophen (APAP) overdose has long been considered a major cause of drug-induced
liver injury. Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid …

Background Ferroptosis is a brand-new type of controlled cell death that is distinguished by
its reliance on iron and the production of lipid peroxidation. The role of ferroptosis in …

Autophagy inhibition is an early cause of drug-induced liver injury (DILI). Cysteine (Cys)
levels in lysosomes are associated with autophagy. Detecting Cys in lysosomes visually is a …

Excess acetaminophen (APAP) commonly causes severe acute liver injury (ALI),
characterized by oxidative stress, pro-inflammatory responses, and hepatocyte damage …

Triphenyl phosphate (TPhP) serves as a major organophosphorus flame retardant, and its
induced neurodevelopmental toxicity has attracted widespread attention, but the mechanism …

Ferroptosis is a novel form of cell death that plays a critical role in the pathological and
physiological processes of early brain injury following subarachnoid hemorrhage …

Acetaminophen (APAP) overdose is steadily becoming the chief reason for drug-induced
acute liver failure, yet limited treatment is currently clinically available. Considering that the …

Oxidative stress plays a critical role in drug-induced liver injury. In recent years, liquiritigenin
(LQ), a natural flavonoid distributed in Glycyrrhizae Radix et Rhizoma (Gan Cao), shows …