Subtype-dependent regulation of Gβγ signalling
G protein-coupled receptors (GPCRs) transmit information to the cell interior by transducing
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …
[HTML][HTML] Rapid assessment of ocular toxicity from environmental contaminants based on visually mediated zebrafish behavior studies
J Yi, Y Ma, J Ma, H Yu, K Zhang, L Jin, Q Yang, D Sun… - Toxics, 2023 - mdpi.com
The presence of contaminants in the environment has increased in recent years, and studies
have demonstrated that these contaminants have the ability to penetrate the blood–retinal …
have demonstrated that these contaminants have the ability to penetrate the blood–retinal …
Trimethyltin chloride induces reactive oxygen species-mediated apoptosis in retinal cells during zebrafish eye development
Trimethyltin chloride (TMT), one of the most widely used organotin compounds in industrial
and agricultural fields, is widespread in soil, aquatic systems, foodstuffs and household …
and agricultural fields, is widespread in soil, aquatic systems, foodstuffs and household …
[HTML][HTML] Intraocular delivery of ZIF-90-RhB-GW2580 nanoparticles prevents the progression of photoreceptor degeneration
P Cao, Y Cheng, Z Li, YJ Cheng, X Chu… - Journal of …, 2023 - Springer
Photoreceptor degeneration is one of the major causes of progressive blindness which lacks
of curative treatment. GW2580, a highly selective inhibitor of colony-stimulating factor 1 …
of curative treatment. GW2580, a highly selective inhibitor of colony-stimulating factor 1 …
[HTML][HTML] Visual function is gradually restored during retina regeneration in adult zebrafish
J Hammer, P Röppenack, S Yousuf… - Frontiers in Cell and …, 2022 - frontiersin.org
In comparison to mammals, zebrafish are able to regenerate many organs and tissues,
including the central nervous system (CNS). Within the CNS-derived neural retina, light …
including the central nervous system (CNS). Within the CNS-derived neural retina, light …
[HTML][HTML] Restoration of cone-circuit functionality in the regenerating adult zebrafish retina
Unlike humans, teleosts like zebrafish exhibit robust retinal regeneration after injury from
endogenous stem cells. However, it is unclear if regenerating cone photoreceptors regain …
endogenous stem cells. However, it is unclear if regenerating cone photoreceptors regain …
The application of methylprednisolone nanoscale zirconium-porphyrin metal-organic framework (MPS-NPMOF) in the treatment of photoreceptor degeneration
Y Wang, W Liu, B Yuan, X Yin, Y Li, Z Li… - International Journal …, 2019 - Taylor & Francis
Background Photoreceptor degeneration is one of the most refractory oculopathy in the
world, leading to vision loss in severe cases. Methyprednisolone is one of the most …
world, leading to vision loss in severe cases. Methyprednisolone is one of the most …
Visual toxicity in zebrafish larvae following exposure to 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47), triphenyl phosphate (TPhP), and isopropyl phenyl diphenyl …
C Luo, Q Zhang, S Zheng, D Wang, W Huang… - Science of The Total …, 2024 - Elsevier
TPhP and IPPP, alternatives to PBDEs as flame retardants, have been studied for their
developmental toxicity, but their visual toxicities are less understood. In this study, zebrafish …
developmental toxicity, but their visual toxicities are less understood. In this study, zebrafish …
The adenosine A (2A) receptor antagonist SCH58261 protects photoreceptors by inhibiting microglial activation and the inflammatory response
Y Cheng, P Cao, C Geng, X Chu, Y Li, J Cui - International …, 2022 - Elsevier
Photoreceptor degeneration is a principal event in a variety of human retinal diseases.
Progressive apoptosis of photoreceptors leads to impaired vision and blindness, for which …
Progressive apoptosis of photoreceptors leads to impaired vision and blindness, for which …
Assessing the chronic exposure of copper oxide and zinc oxide nanoparticles in zebrafish
Objective In the present time, nanomaterial toxicological studies have become important due
to the persistent presence of engineered nanomaterials in the environment. Zebrafish are a …
to the persistent presence of engineered nanomaterials in the environment. Zebrafish are a …