Subtype-dependent regulation of Gβγ signalling

M Tennakoon, K Senarath, D Kankanamge… - Cellular signalling, 2021 - Elsevier
G protein-coupled receptors (GPCRs) transmit information to the cell interior by transducing
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …

[HTML][HTML] Rapid assessment of ocular toxicity from environmental contaminants based on visually mediated zebrafish behavior studies

J Yi, Y Ma, J Ma, H Yu, K Zhang, L Jin, Q Yang, D Sun… - Toxics, 2023 - mdpi.com
The presence of contaminants in the environment has increased in recent years, and studies
have demonstrated that these contaminants have the ability to penetrate the blood–retinal …

Trimethyltin chloride induces reactive oxygen species-mediated apoptosis in retinal cells during zebrafish eye development

J Kim, C Kim, H Oh, B Ryu, U Kim, JM Lee… - Science of the total …, 2019 - Elsevier
Trimethyltin chloride (TMT), one of the most widely used organotin compounds in industrial
and agricultural fields, is widespread in soil, aquatic systems, foodstuffs and household …

[HTML][HTML] Intraocular delivery of ZIF-90-RhB-GW2580 nanoparticles prevents the progression of photoreceptor degeneration

P Cao, Y Cheng, Z Li, YJ Cheng, X Chu… - Journal of …, 2023 - Springer
Photoreceptor degeneration is one of the major causes of progressive blindness which lacks
of curative treatment. GW2580, a highly selective inhibitor of colony-stimulating factor 1 …

[HTML][HTML] Visual function is gradually restored during retina regeneration in adult zebrafish

J Hammer, P Röppenack, S Yousuf… - Frontiers in Cell and …, 2022 - frontiersin.org
In comparison to mammals, zebrafish are able to regenerate many organs and tissues,
including the central nervous system (CNS). Within the CNS-derived neural retina, light …

[HTML][HTML] Restoration of cone-circuit functionality in the regenerating adult zebrafish retina

E Abraham, H Hartmann, T Yoshimatsu, T Baden… - Developmental Cell, 2024 - cell.com
Unlike humans, teleosts like zebrafish exhibit robust retinal regeneration after injury from
endogenous stem cells. However, it is unclear if regenerating cone photoreceptors regain …

The application of methylprednisolone nanoscale zirconium-porphyrin metal-organic framework (MPS-NPMOF) in the treatment of photoreceptor degeneration

Y Wang, W Liu, B Yuan, X Yin, Y Li, Z Li… - International Journal …, 2019 - Taylor & Francis
Background Photoreceptor degeneration is one of the most refractory oculopathy in the
world, leading to vision loss in severe cases. Methyprednisolone is one of the most …

Visual toxicity in zebrafish larvae following exposure to 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47), triphenyl phosphate (TPhP), and isopropyl phenyl diphenyl …

C Luo, Q Zhang, S Zheng, D Wang, W Huang… - Science of The Total …, 2024 - Elsevier
TPhP and IPPP, alternatives to PBDEs as flame retardants, have been studied for their
developmental toxicity, but their visual toxicities are less understood. In this study, zebrafish …

The adenosine A (2A) receptor antagonist SCH58261 protects photoreceptors by inhibiting microglial activation and the inflammatory response

Y Cheng, P Cao, C Geng, X Chu, Y Li, J Cui - International …, 2022 - Elsevier
Photoreceptor degeneration is a principal event in a variety of human retinal diseases.
Progressive apoptosis of photoreceptors leads to impaired vision and blindness, for which …

Assessing the chronic exposure of copper oxide and zinc oxide nanoparticles in zebrafish

J Kaur, H Singh, S Puri, M Khatri - Toxicology and Environmental Health …, 2024 - Springer
Objective In the present time, nanomaterial toxicological studies have become important due
to the persistent presence of engineered nanomaterials in the environment. Zebrafish are a …