Over the last two decades, an exponentially expanding number of genetic variants have
been identified associated with inherited cardiac conditions. These tremendous gains also …

Abstract Background and Purpose To protect against SARS‐CoV‐2 infection, the first mRNA‐
based vaccines, Spikevax (mRNA‐1273, Moderna) and Comirnaty (BNT162b2 …

RNA splicing is an important RNA processing step required by multiexon protein-coding
mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene …

Ryanodine receptor 2 (RyR2) hyperactivity is observed in structural heart diseases that are a
result of ischemia or heart failure. It causes abnormal calcium handling and calcium leaks …

Objective To utilize whole exome or genome sequencing and the scientific literature for
identifying candidate genes for cyclic vomiting syndrome (CVS), an idiopathic migraine …

The oligomeric form of the peptide amyloid beta 42 (Abeta42) contributes to the
development of synaptic abnormalities and cognitive impairments associated with …

Calcium (Ca2+) is the major mediator of cardiac contractile function. It plays a key role in
regulating excitation–contraction coupling and modulating the systolic and diastolic phases …

Heart failure (HF) is recognized as an epidemic in the contemporary world, impacting
around 1%–2% of the adult population and affecting around 6 million Americans. HF …

Cardiac tachyarrhythmia presents a significant healthcare challenge, causing notable
morbidity and mortality. Conventional treatments have limitations and potential risks …

Cetaceans could be seen as a natural experiment within the tree of life in which a
mammalian lineage changed from terrestrial to aquatic habitats. This shift involved extensive …