Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Cells are exquisitely compartmentalized to achieve precise spatiotemporal regulation of
myriad processes and pathways. Phase separation offers one way to achieve territorial …

Thousands of genetic variants in protein-coding genes have been linked to disease.
However, the functional impact of most variants is unknown as they occur within intrinsically …

The formation of biomolecular condensates mediated by a coupling of associative and
segregative phase transitions plays a critical role in controlling diverse cellular functions in …

Condensed states of proteins, including liquid-like membraneless organelles and solid-like
aggregates, contribute in fundamental ways to the organisation and function of the cell …

In eukaryotes, end-binding (EB) proteins serve as a hub for orchestrating microtubule
dynamics and are essential for cellular dynamics and organelle movements. EB proteins …

The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …

A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …

Summary Cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA is critical for the
immune response to cancer and pathogen infection. Here, we discover that cGAS-DNA …

A multitude of cellular processes involve biomolecular condensates, which has led to the
suggestion that diverse pathogenic mutations may dysregulate condensates. Although proof …