Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide.
Until now, treatments for depression have focused on the inhibition of monoaminergic …

Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic
AMP-responsive-element-binding protein (CREB) signal system may be involved in the …

What changes in brain function cause the debilitating symptoms of depression? Can we use
the answers to this question to invent more effective, faster acting antidepressant drug …

Emotional stress has been recognized as a modifiable risk factor for cardiovascular
diseases. The impact of stress on physiological and psychological processes is determined …

Rationale Many studies support the validity of the chronic mild stress (CMS) model of
depression in rodents. However, most of them focus on analysis of reactivity to rewards …

BACKGROUND: A growing body of evidence suggests a disturbance of brain plasticity in
major depression. In contrast to hippocampal neurogenesis, much less is known about the …

Honokiol and magnolol are the main constituents simultaneously identified in the barks of
Magnolia officinalis, which have been used in traditional Chinese medicine to treat a variety …

Rimonabant was the first clinically marketed cannabinoid (CB) 1 receptor antagonist
developed to treat obesity. Unfortunately, CB1 receptor antagonism produced adverse …

Stress is an adaptive response to demands of the environment and thus essential for
survival. Exposure to stress during the first years of life has been shown to have profound …

BACKGROUND: The onset of major depressive disorder is likely precipitated by a
combination of heredity and life stress. The present study tested the hypothesis that rats …