Atrophy occurs in specific muscles with inactivity (for example, during plaster cast
immobilization) or denervation (for example, in patients with spinal cord injuries). Muscle …

Since the discovery of myostatin (MSTN; also known as GDF-8) as a critical regulator of
skeletal muscle mass in 1997, there has been an extensive effort directed at understanding …

In the context of the coronavirus disease 2019 (COVID-19) pandemic, the global healthcare
community has raced to find effective therapeutic agents against severe acute respiratory …

Myostatin is a negative regulator of skeletal muscle growth secreted by skeletal myocytes. In
the past years, myostatin inhibition sparked interest among the scientific community for its …

Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …

Glucocorticoids are known to regulate protein metabolism in skeletal muscle, producing a
catabolic effect that is opposite that of insulin. In many catabolic diseases, such as sepsis …

Background Skeletal muscle atrophy is defined as a reduction of muscle mass caused by
excessive protein degradation. However, the development of therapeutic interventions is still …

Purpose To determine the individual and combined effects of 12 weeks of resistance
exercise (RE) and whey protein supplementation on skeletal muscle strength (primary …

Muscle wasting disease indications are among the most debilitating and often deadly
noncommunicable disease states. As a comorbidity, muscle wasting is associated with …

Anti-inflammatory modalities are commonly used for the treatment of various
musculoskeletal injuries. Although inflammation was originally believed to interfere with …