Therapeutic effects of apamin as a bee venom component for non-neoplastic disease

H Gu, SM Han, KK Park - Toxins, 2020 - mdpi.com
Bee venom is a natural toxin produced by honeybees and plays an important role in
defending bee colonies. Bee venom has several kinds of peptides, including melittin …

Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer's disease

Q Sun, J Zhang, A Li, M Yao, G Liu, S Chen… - Nature …, 2022 - nature.com
Short-term memory deficits have been associated with prefrontal cortex (PFC) dysfunction in
Alzheimer's disease (AD) and AD mouse models. Extratelencephalic projection (ET) …

[HTML][HTML] SK2 channel regulation of neuronal excitability, synaptic transmission, and brain rhythmic activity in health and diseases

J Sun, Y Liu, M Baudry, X Bi - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Small conductance calcium-activated potassium channels (SKs) are solely activated by
intracellular Ca 2+ and their activation leads to potassium efflux, thereby repolarizing …

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I  …

M Ortiz-Virumbrales, CL Moreno, I Kruglikov… - Acta neuropathologica …, 2017 - Springer
Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to
be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short …

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

K Xhima, K Markham-Coultes, R Hahn Kofoed… - Brain, 2022 - academic.oup.com
Early degeneration of basal forebrain cholinergic neurons contributes substantially to
cognitive decline in Alzheimer's disease. Evidence from preclinical models of neuronal …

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer's disease: An update

C Villa, H Suphesiz, R Combi, E Akyuz - Mechanisms of ageing and …, 2020 - Elsevier
With more than 80 subunits, potassium (K+) channels represent a group of ion channels
showing high degree of diversity and ubiquity. They play important role in the control of …

[HTML][HTML] Calcium-activated potassium channels: Implications for aging and age-related neurodegeneration

M Trombetta-Lima, IE Krabbendam… - The International Journal of …, 2020 - Elsevier
Population aging, as well as the handling of age-associated diseases, is a worldwide
increasing concern. Among them, Alzheimer's disease stands out as the major cause of …

Amyloid beta alters prefrontal-dependent functions along with its excitability and synaptic plasticity in male rats

M Torres-Flores, F Peña-Ortega - Neuroscience, 2022 - Elsevier
Prefrontal cortex (PFC)-related functions, such as working memory (WM) and cognitive
flexibility (CF), are among the first to be altered at early stages of Alzheimer's disease (AD) …

Selective impairment of circuits between prefrontal cortex glutamatergic neurons and basal forebrain cholinergic neurons in a tauopathy mouse model

P Zhong, Q Cao, Z Yan - Cerebral Cortex, 2022 - academic.oup.com
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder linked to cognitive
decline. To understand how specific neuronal circuits are impaired in AD, we have used …

Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease

M Wei, T Wu, N Chen - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder. As the demographic shifting
towards an aging population, AD has emerged as a prominent public health concern. The …