Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory …
The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …
has been one of the most significant biochemical and pharmacological advancements to …
Neurobiology of cannabinoid receptor signaling
B Lutz - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …
system. Despite its widespread localization, its functions within the context of distinct neural …
SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
O Durydivka, K Mackie, J Blahos - Frontiers in Neuroscience, 2023 - frontiersin.org
In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially
expressed in axons where it has a unique property, namely resistance to agonist-driven …
expressed in axons where it has a unique property, namely resistance to agonist-driven …
Protein interactors and trafficking pathways that regulate the cannabinoid type 1 receptor (CB1R)
A Fletcher-Jones, KL Hildick, AJ Evans… - Frontiers in molecular …, 2020 - frontiersin.org
The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress
synaptic transmission and plays a major role in a diverse range of brain functions including …
synaptic transmission and plays a major role in a diverse range of brain functions including …
Mechanisms of selective G protein–coupled receptor localization and trafficking
JM Kunselman, J Lott, MA Puthenveedu - Current opinion in cell biology, 2021 - Elsevier
The trafficking of G protein–coupled receptors (GPCRs) to different membrane
compartments has recently emerged as being a critical determinant of the signaling profiles …
compartments has recently emerged as being a critical determinant of the signaling profiles …
Identification of BiP as a CB1 receptor-interacting protein that fine-tunes cannabinoid signaling in the mouse brain
Cannabinoids, the bioactive constituents of cannabis, exert a wide array of effects on the
brain by engaging Type 1 cannabinoid receptor (CB1R). Accruing evidence supports that …
brain by engaging Type 1 cannabinoid receptor (CB1R). Accruing evidence supports that …
SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression
A Fletcher-Jones, E Spackman, TJ Craig… - Journal of Cell …, 2024 - journals.biologists.com
Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as
CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses …
CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses …
Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons
Neurotransmitter-filled synaptic vesicles (SVs) mediate synaptic transmission and are a
hallmark specialization in neuronal axons. Yet, how SV proteins are sorted to presynaptic …
hallmark specialization in neuronal axons. Yet, how SV proteins are sorted to presynaptic …
Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3
Neuregulins (NRGs) are EGF-like ligands associated with cognitive disorders. Unprocessed
proNRG3 is cleaved by BACE1 to generate the mature membrane-bound NRG3 ligand, but …
proNRG3 is cleaved by BACE1 to generate the mature membrane-bound NRG3 ligand, but …
Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance
TMM Saez, I Fernandez Bessone… - …, 2020 - journals.biologists.com
Endocannabinoids (eCB) modulate growth cone dynamics and axonal pathfinding through
the stimulation of cannabinoid type-1 receptors (CB1R), the function of which depends on …
the stimulation of cannabinoid type-1 receptors (CB1R), the function of which depends on …