Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …

Cellular senescence is a stress response elicited by different molecular insults. Senescence
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …

Although CRISPR-mediated genome editing holds promise for cancer therapy, inadequate
tumor targeting and potential off-target side effects hamper its outcomes. In this study, we …

Malignant pleural mesothelioma (MPM) is a highly invasive form of lung cancer that
adversely affects the pleural and other linings of the lungs. MPM is a very aggressive tumor …

Abnormal increases in cell size are associated with senescence and cell cycle exit. The
mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain …

Sex steroids are major promoters of the growth of breast and prostate cancers. This Review
by Poutanen et al. describes the development of treatments for these cancer types that act to …

Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over
CDK6 is prominent for improving drug design towards the CDK family. Multiple short …

Chronic inflammation promotes development and progression of colorectal cancer (CRC).
To comprehensively understand the molecular mechanisms underlying the development …

Abstract Cyclin-dependent kinase 2 (CDK2) is thought to play an important role in driving
proliferation of certain cancers, including those harboring CCNE1 amplification and breast …

The dysregulation of the cell cycle is one of the hallmarks of cancer. Cyclin-dependent
kinase 4 (CDK4) and CDK6 play crucial roles in regulating cell cycle and other cellular …