Dual role of autophagy in hallmarks of cancer
Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …
intracellular catabolic degradative process targeting damaged and superfluous cellular …
Genomic analysis of circulating tumor DNA in 3,334 patients with advanced prostate cancer identifies targetable BRCA alterations and AR resistance mechanisms
H Tukachinsky, RW Madison, JH Chung… - Clinical Cancer …, 2021 - AACR
Purpose: Comprehensive genomic profiling (CGP) is of increasing value for patients with
metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to …
metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to …
[HTML][HTML] Comprehensive analysis of normal adjacent to tumor transcriptomes
Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in
cancer studies. However, little is known about the transcriptomic profile of NAT, how it is …
cancer studies. However, little is known about the transcriptomic profile of NAT, how it is …
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed
therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low …
therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low …
PROREPAIR-B: a prospective cohort study of the impact of germline DNA repair mutations on the outcomes of patients with metastatic castration-resistant prostate …
Purpose Germline mutations in DNA damage repair (DDR) genes are identified in a
significant proportion of patients with metastatic prostate cancer, but the clinical implications …
significant proportion of patients with metastatic prostate cancer, but the clinical implications …
[HTML][HTML] Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer
BACKGROUND. Liquid biopsies have demonstrated that the constitutively active androgen
receptor splice variant-7 (AR-V7) associates with reduced response and overall survival …
receptor splice variant-7 (AR-V7) associates with reduced response and overall survival …
[HTML][HTML] Widespread and functional RNA circularization in localized prostate cancer
The cancer transcriptome is remarkably complex, including low-abundance transcripts,
many not polyadenylated. To fully characterize the transcriptome of localized prostate …
many not polyadenylated. To fully characterize the transcriptome of localized prostate …
Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma
T Vagner, C Spinelli, VR Minciacchi… - Journal of …, 2018 - Taylor & Francis
Cancer-derived extracellular vesicles (EVs) are membrane-enclosed structures of highly
variable size. EVs contain a myriad of substances (proteins, lipid, RNA, DNA) that provide a …
variable size. EVs contain a myriad of substances (proteins, lipid, RNA, DNA) that provide a …
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
M Zimmermann, O Murina, MAM Reijns… - Nature, 2018 - nature.com
The observation that BRCA1-and BRCA2-deficient cells are sensitive to inhibitors of poly
(ADP–ribose) polymerase (PARP) has spurred the development of cancer therapies that use …
(ADP–ribose) polymerase (PARP) has spurred the development of cancer therapies that use …
[HTML][HTML] Genomics of lethal prostate cancer at diagnosis and castration resistance
The genomics of primary prostate cancer differ from those of metastatic castration-resistant
prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer …
prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer …