With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

The burgeoning field of epigenetics offers transformative insights into the complex
landscape of neurological and psychiatric disorders. By unraveling the intricate interplay …

Animal models of psychiatric disorders have been highly effective in advancing the field,
identifying circuits related to pathophysiology, and identifying novel therapeutic targets. In …

Brain aging, which involves a progressive loss of neuronal functions, has been reported to
be premature in probands affected by schizophrenia (SCZ). Evidence shows that SCZ and …

Abstract Treatment-resistant schizophrenia (TRS) is defined as a non-response to at least
two trials of antipsychotic medication with an adequate dose and duration. We aimed to …

The aberrant aging hypothesis of schizophrenia (SCZ) and autism spectrum disorder (ASD)
has been proposed, and the DNA methylation (DNAm) clock, which is a cumulative …

The adenosine hypothesis of schizophrenia was conceptualized about two decades ago in
an attempt to integrate two prominent theories of neurochemical imbalance that attribute the …

Background Antipsychotic treatment has been conceived to alter brain connectivity, but it is
unclear how the changes of network phenotypes relate to the underlying transcriptomics …

Background: Schizophrenia is a grave and incapacitating global mental health challenge.
Prior research has proposed various psychological interventions aimed at alleviating the …

Background Volumetric alterations of subcortical structures as predictors of antipsychotic
treatment response have been previously corroborated, but less is known about whether …