Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

The third international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation

CN Kotton, D Kumar, AM Caliendo, S Huprikar… - …, 2018 - journals.lww.com
Despite recent advances, cytomegalovirus (CMV) infections remain one of the most common
complications affecting solid organ transplant recipients, conveying higher risks of …

Maribavir for refractory cytomegalovirus infections with or without resistance post-transplant: results from a phase 3 randomized clinical trial

RK Avery, S Alain, BD Alexander… - Clinical Infectious …, 2022 - academic.oup.com
Background Therapies for refractory cytomegalovirus infections (with or without resistance
[R/R]) in transplant recipients are limited by toxicities. Maribavir has multimodal anti …

Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation

FM Marty, P Ljungman, RF Chemaly… - … England Journal of …, 2017 - Mass Medical Soc
Background Cytomegalovirus (CMV) infection remains a common complication after
allogeneic hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the …

Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European …

P Ljungman, R de la Camara, C Robin… - The Lancet infectious …, 2019 - thelancet.com
Cytomegalovirus is one of the most important infections to occur after allogeneic
haematopoietic stem cell transplantation (HSCT), and an increasing number of reports …

Definitions of cytomegalovirus infection and disease in transplant patients for use in clinical trials

P Ljungman, M Boeckh, HH Hirsch… - Clinical Infectious …, 2016 - academic.oup.com
Cytomegalovirus (CMV) infection and disease are important causes of morbidity and
mortality in transplant recipients. For the purpose of developing consistent reporting of CMV …

Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis

P Teira, M Battiwalla, M Ramanathan… - Blood, The Journal …, 2016 - ashpublications.org
Single-center studies have reported an association between early (before day 100)
cytomegalovirus (CMV) reactivation and decreased incidence of relapse for acute myeloid …

The pathogenesis of human cytomegalovirus

P Griffiths, I Baraniak, M Reeves - The Journal of pathology, 2015 - Wiley Online Library
Human cytomegalovirus (HCMV) is a recognized cause of disease in the fetus, the allograft
recipient and AIDS patients. More recently, it has been recognized as a pathogen for those …

Cytomegalovirus viral load and mortality after haemopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study

ML Green, W Leisenring, HU Xie, TC Mast… - The Lancet …, 2016 - thelancet.com
Background Although cytomegalovirus viral load is commonly used to guide pre-emptive
therapy in the post-transplantation setting, few data are available correlating viraemia with …

Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation

CN Kotton, D Kumar, AM Caliendo, A Åsberg… - …, 2013 - journals.lww.com
Cytomegalovirus (CMV) continues to be one of the most common infections after solid-organ
transplantation, resulting in significant morbidity, graft loss, and adverse outcomes …