Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …

Actin is among the most abundant proteins in eukaryotic cells and assembles into dynamic
filamentous networks regulated by many actin binding proteins. The actin cytoskeleton must …

Methionine (Met) can be oxidized to methionine sulfoxide (MetO), which exist as R-and S-
diastereomers. Present in all three domains of life, methionine sulfoxide reductases (MSR) …

Branched actin filaments are found in many key cellular structures. Branches are nucleated
by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to …

Regulation of the Arp2/3 complex is required for productive nucleation of branched actin
networks. An emerging aspect of regulation is the incorporation of subunit isoforms into the …

Actin and its dynamic structural remodelings are involved in multiple cellular functions,
including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle …

The central amygdala (CeA) consists of numerous genetically defined inhibitory neurons
that control defensive and appetitive behaviors including feeding. Transcriptomic signatures …

The actin cytoskeleton impacts practically every function of a eukaryotic cell. Historically, the
best-characterized cytoskeletal activities are in cell morphogenesis, motility, and division …

Immune cells exhibit low-level, constitutive signaling at rest (tonic signaling). Such tonic
signals are required for fundamental processes, including the survival of B lymphocytes, but …

The Arp2/3 complex drives the formation of branched actin networks that are essential for
many cellular processes. In humans, the ARPC5 subunit of the Arp2/3 complex is encoded …