Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament
The actin cytoskeleton can form many different types of dynamic supramolecular arrays-from
linear bundles to branched actin filament networks which underlie its functional diversity and …
linear bundles to branched actin filament networks which underlie its functional diversity and …
[HTML][HTML] ARPC1B binds WASP to control actin polymerization and curtail tonic signaling in B cells
G Leung, Y Zhou, P Ostrowski, S Mylvaganam… - JCI insight, 2021 - ncbi.nlm.nih.gov
Immune cells exhibit low-level, constitutive signaling at rest (tonic signaling). Such tonic
signals are required for fundamental processes, including the survival of B lymphocytes, but …
signals are required for fundamental processes, including the survival of B lymphocytes, but …
CRISPR-Cas9 Arabidopsis mutants of genes for ARPC1 and ARPC3 subunits of ARP2/3 complex reveal differential roles of complex subunits
Protein complex Arp2/3 has a conserved role in the nucleation of branched actin filaments. It
is constituted of seven subunits, including actin-like subunits ARP2 and ARP3 plus five other …
is constituted of seven subunits, including actin-like subunits ARP2 and ARP3 plus five other …
The relative binding position of Nck and Grb2 adaptors impacts actin-based motility of Vaccinia virus
Phosphotyrosine (pTyr) motifs in unstructured polypeptides orchestrate important cellular
processes by engaging SH2-containing adaptors to assemble complex signalling networks …
processes by engaging SH2-containing adaptors to assemble complex signalling networks …
ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells
L Sadhu, N Tsopoulidis, M Hasanuzzaman, V Laketa… - Elife, 2023 - elifesciences.org
CD4 T cell activation induces nuclear and cytoplasmic actin polymerization via the Arp2/3
complex to activate cytokine expression and strengthen T cell receptor (TCR) signaling …
complex to activate cytokine expression and strengthen T cell receptor (TCR) signaling …
CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes
The inhibitors, CK-666 and CK-869, are widely used to probe the function of Arp2/3 complex
mediated actin nucleation in vitro and in cells. However, in mammals, the Arp2/3 complex …
mediated actin nucleation in vitro and in cells. However, in mammals, the Arp2/3 complex …
The amount of Nck rather than N-WASP correlates with the rate of actin-based motility of Vaccinia virus
Vaccinia virus exiting from host cells activates Src/Abl kinases to phosphorylate A36, an
integral membrane viral protein. Phosphorylated A36 binds the adaptors Nck and Grb2 …
integral membrane viral protein. Phosphorylated A36 binds the adaptors Nck and Grb2 …
MICAL1 activation by PAK1 mediates actin filament disassembly
DJ McGarry, G Castino, S Lilla, A Carnet, L Kelly… - Cell Reports, 2022 - cell.com
The MICAL1 monooxygenase is an important regulator of filamentous actin (F-actin)
structures. Although MICAL1 has been shown to be regulated via protein-protein …
structures. Although MICAL1 has been shown to be regulated via protein-protein …
Biomimetic actin cortices shape cell-sized lipid vesicles
Animal cells are shaped by a thin layer of actin filaments underneath the plasma membrane
known as the actin cortex. This cortex stiffens the cell surface and thus opposes cellular …
known as the actin cortex. This cortex stiffens the cell surface and thus opposes cellular …
[HTML][HTML] Evolutionary diversification reveals distinct somatic versus germline cytoskeletal functions of the Arp2 branched actin nucleator protein
KA Stromberg, T Spain, SA Tomlin, J Powell… - Current Biology, 2023 - cell.com
Branched actin networks are critical in many cellular processes, including cell motility and
division. Arp2, a protein within the seven-membered Arp2/3 complex, is responsible for …
division. Arp2, a protein within the seven-membered Arp2/3 complex, is responsible for …