Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Consumer and environmental safety decisions are based on exposure and hazard data,
interpreted using risk assessment approaches. The adverse outcome pathway (AOP) …

Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a
handful of compounds. These compounds stimulate the development of steatohepatitis …

Drug-induced liver injury (DILI) is an important cause of liver toxicity which can have varying
clinical presentations, the most severe of which being acute liver failure. Hepatocyte death …

Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for
various physiological activities of the cell. Cardiomyocytes have a high density of …

In their clinical practice, physicians can face heart diseases (chronic or acute heart failure)
affecting the liver and liver diseases affecting the heart. Systemic diseases can also affect …

Abstract Chinese herb Rhubarb (Dahuang), one of the most widely used traditional Chinese
medicine in clinical application for over a thousand years and known as the “General (Jiang …

Aluminum (Al) is known to exert hepatotoxicity. However, the mechanisms mostly are
unclear. Liver is a metabolism organ that maintains the energy level and structural stability of …