Immuno-oncology approaches have entered clinical practice, with tremendous progress
particularly in the field of T cell-engaging therapies over the past decade. Herein, we provide …

Importance The emerging approach of neoadjuvant immunotherapy for solid cancers has
set the ground for the integration of programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) …

Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx,
oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide …

Head and neck squamous cell carcinoma (HNSCC) encompass a group of complex entities
of tumours affecting the aerodigestive upper tract. The main risk factors are strongly related …

Despite the remarkable success of immunotherapy in many types of cancer, pancreatic
ductal adenocarcinoma has yet to benefit. Innate immune cells are critical to anti-tumor …

Immunotherapy revolutionized cancer treatment but has yet to elicit durable responses in the
majority of patients with head and neck squamous cell carcinoma (HNSCC). HNSCC is …

Simple Summary Cancers in the head and neck region are often aggressive and poorly
respond to both irradiation or chemotherapy. Chemotherapy is currently limited by a small …

Purpose: Nectin-4 has been successfully established as a target molecule in locally
advanced and metastatic bladder cancer. An antibody-drug conjugate (enfortumab-vedotin) …

Human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC)
is a common cancer worldwide with an unmet need for more effective, less toxic treatments …

Engineered viral vectors represent a promising strategy to trigger antigen-specific antitumor
T cell responses. Arenaviruses have been widely studied because of their ability to elicit …