[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease
Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …
Trajectories of kidney function in diabetes: a clinicopathological update
M Oshima, M Shimizu, M Yamanouchi… - Nature Reviews …, 2021 - nature.com
Diabetic nephropathy has been traditionally diagnosed based on persistently high
albuminuria and a subsequent decline in glomerular filtration rate (GFR), which is widely …
albuminuria and a subsequent decline in glomerular filtration rate (GFR), which is widely …
[HTML][HTML] Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …
Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
Sitagliptin treatment at the time of hospitalization was associated with reduced mortality in patients with type 2 diabetes and COVID-19: a multicenter, case-control …
SB Solerte, F D'Addio, R Trevisan, E Lovati… - Diabetes …, 2020 - Am Diabetes Assoc
OBJECTIVE Poor outcomes have been reported in patients with type 2 diabetes and
coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic …
coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic …
[PDF][PDF] Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis
Fibrosis is the final common pathway leading to end-stage renal failure. By analyzing the
kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial …
kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial …
Innate immunity in diabetic kidney disease
SCW Tang, WH Yiu - Nature Reviews Nephrology, 2020 - nature.com
Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …
[HTML][HTML] Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function
Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …
The single-cell transcriptomic landscape of early human diabetic nephropathy
PC Wilson, H Wu, Y Kirita, K Uchimura… - Proceedings of the …, 2019 - National Acad Sciences
Diabetic nephropathy is characterized by damage to both the glomerulus and
tubulointerstitium, but relatively little is known about accompanying cell-specific changes in …
tubulointerstitium, but relatively little is known about accompanying cell-specific changes in …
[HTML][HTML] Chronic inflammation in chronic kidney disease progression: role of Nrf2
Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …
and mortality rates in these patients remain high. While pressure-mediated injury is a well …