Anxiety is a psychological, physiological, and behavioral state induced in animals and
humans by a threat to well-being or survival, either actual or potential. It is characterized by …

In various areas of the bio-medical, pharmacological and psychological research a multitude
of behavioural tests have been used to investigate the effects of environmental, genetic and …

Psychiatry has proven to be among the least penetrable clinical disciplines for the
development of satisfactory in vivo model systems for evaluating novel treatment …

Rationale An increasing number of investigators utilize the marble-burying assay despite the
paucity of information available regarding what underlies the behavior. Objectives We tested …

The plus-maze, the light–dark box and the open-field are the main current tests of
unconditioned anxiety for mice and rats. Despite their disappointing achievements, they …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Three defining clinical symptoms of autism are aberrant reciprocal social interactions,
deficits in social communication, and repetitive behaviors, including motor stereotypies and …

Brain-derived neurotrophic factor has been associated previously with the regulation of food
intake. To help elucidate the role of this neurotrophin in weight regulation, we have …

Our laboratory uses a specific test battery for the initial assessment of phenotypic behavioral
differences of transgenic, knockout, and inbred strains of mice. Our standard battery …

Animal models can certainly be useful to find out more about the biological bases of anxiety
disorders and develop new, more efficient pharmacological and/or behavioral treatments …