Chronic myelogenous leukemia: a review

JE Cortes, M Talpaz, H Kantarjian - The American journal of medicine, 1996 - Elsevier
Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disorder with an
initially chronic course lasting for 3–5 years. It eventually transforms into accelerated and …

Harnessing graft-versus-malignancy: non-myeloablative preparative regimens for allogeneic haematopoietic transplantation, an evolving strategy for adoptive …

R Champlin, I Khouri, A Shimoni… - British journal of …, 2000 - search.ebscohost.com
Examines the association of the therapeutic benefit of allogeneic bone marrow
transplantation with immune-mediated graft-versus-malignancy effect. Information on graft …

Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals

C Biernaux, M Loos, A Sels, G Huez, P Stryckmans - 1995 - ashpublications.org
The major bcr-abl fusion gene is presently seen as the hallmark of chronic myeloid leukemia
(CML) and presumably as the cause of its development. Accordingly, long-term …

Complete cytogenetic and molecular responses to interferon‐α‐based therapy for chronic myelogenous leukemia are associated with excellent long‐term prognosis

HM Kantarjian, S O'Brien, JE Cortes… - … Journal of the …, 2003 - Wiley Online Library
BACKGROUND Little is known regarding long‐term prognosis among patients with
Philadelphia chromosome (Ph)‐positive chronic myelogenous leukemia (CML) who achieve …

CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation

S Giralt, J Hester, Y Huh, C Hirsch-Ginsberg, G Rondon… - 1995 - ashpublications.org
Donor lymphocyte infusions can reinduce complete remission in the majority of patients with
chronic myelogenous leukemia (CML) who relapse into chronic phase after allogeneic bone …

Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in …

JP Radich, G Gehly, T Gooley, E Bryant, RA Clift… - 1995 - ashpublications.org
We studied 346 patients after bone marrow transplantation (BMT) for chronic myeloid
leukemia (CML) for the presence of the bcr-abl transcript detected by the polymerase chain …

Detection of bcr-abl Transcripts in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia After Marrow Transplantation

J Radich, G Gehly, A Lee, R Avery… - Blood, The Journal …, 1997 - ashpublications.org
Thirty-six patients with Philadelphia chromosome–positive acute lymphoblastic leukemia
(Ph+ ALL) were studied for the presence of the bcr-abl fusion mRNA transcript after an …

Chronic myelogenous leukemia: a review and update of therapeutic strategies

G Garcia-Manero, S Faderl, S O'Brien… - …, 2003 - mdanderson.elsevierpure.com
The prognosis of patients with chronic myelogenous leukemia (CML) has significantly
improved over the last 20 years. Whereas the median survival durations were 4-5 years in …

[HTML][HTML] Detection of minimal residual disease in acute promyelocytic leukemia by a reverse transcription polymerase chain reaction assay for the PML/RAR-α fusion …

WH Miller Jr, K Levine, A DeBlasio, SR Frankel… - Blood, 1993 - Elsevier
The characteristic reciprocal translocation t (15; 17) of acute promyelocytic leukemia (APL)
disrupts the PML gene on chromosome 15 and the retinoic acid receptor-α (RAR-α) gene on …

Early detection of BCR-ABL transcripts by quantitative reverse transcriptase–polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for …

E Olavarria, E Kanfer, R Szydlo, J Kaeda… - Blood, The Journal …, 2001 - ashpublications.org
The reverse transcriptase–polymerase chain reaction (RT-PCR) has become widely used
for monitoring minimal residual disease after allogeneic stem cell transplantation (SCT) for …