Oxidative stress, inflammation and androgen receptor (AR) signaling play a pivotal role in
the initiation, development and progression of prostate cancer (PCa). Numerous papers in …

Androgen receptor (AR) signaling plays a key role not only in the initiation of prostate cancer
(PCa) but also in its transition to aggressive and invasive castration-resistant prostate cancer …

The role of truncated androgen receptor splice variant-7 (AR-V7) in prostate cancer biology
is an unresolved question. Is it simply a marker of resistance to 2nd-generation androgen …

Purpose: Persistent androgen receptor (AR) signaling drives castration-resistant prostate
cancer (CRPC) and confers resistance to AR-targeting therapies. Novel therapeutic …

Advanced-stage prostate cancer remains an incurable disease with poor patient prognosis.
There is an unmet clinical need to target androgen receptor (AR) splice variants, which are …

Background Androgen receptor splice variant 7 (AR-V7) has been implicated in resistance
to abiraterone and enzalutamide treatment in men with metastatic castration-resistant …

Blocking androgen receptor signaling is the mainstay of therapy for advanced prostate
cancer (PCa). However, acquired resistance to single agents targeting this pathway results …

The oncogenic activation of the ETS-related gene (ERG) due to gene fusions is present in
over half of prostate cancers in Western countries. Because of its high incidence and …

The aging-associated increase of cancer risk is linked with stromal fibroblast senescence
and concomitant cancer-associated fibroblast (CAF) activation. Surprisingly little is known …

Abstract BCL-2–associated athanogene-1L (BAG-1L) is a critical co-regulator that binds to
and enhances the transactivation function of the androgen receptor, leading to prostate …