Advances in model systems for human cytomegalovirus latency and reactivation

LB Crawford, NL Diggins, P Caposio, MH Hancock - MBio, 2022 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is a highly prevalent beta-herpesvirus and a significant
cause of morbidity and mortality following hematopoietic and solid organ transplant, as well …

[HTML][HTML] Hematopoietic stem cells and betaherpesvirus latency

LB Crawford - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
The human betaherpesviruses including human cytomegalovirus (HCMV), human
herpesvirus (HHV)-6a and HHV-6b, and HHV-7 infect and establish latency in CD34+ …

[PDF][PDF] Human cytomegalovirus miRNAs regulate TGF-β to mediate myelosuppression while maintaining viral latency in CD34+ hematopoietic progenitor cells

MH Hancock, LB Crawford, AH Pham, J Mitchell… - Cell host & …, 2020 - cell.com
Infection with human cytomegalovirus (HCMV) remains a significant cause of morbidity and
mortality following hematopoietic stem cell transplant (HSCT) because of various …

CD34+ Hematopoietic Progenitor Cell Subsets Exhibit Differential Ability To Maintain Human Cytomegalovirus Latency and Persistence

LB Crawford, MH Hancock, HM Struthers… - Journal of …, 2021 - Am Soc Microbiol
In human cytomegalovirus (HCMV)-seropositive patients, CD34+ hematopoietic progenitor
cells (HPCs) provide an important source of latent virus that reactivates following cellular …

The golden doses of anti CD3/CD28 microbeads plus IL-15 promote expansion of specific T cells in human cytomegalovirus adaptive immunotherapy

A Jalili, N Aghdami, A Hajifathali… - Health …, 2023 - healthbiotechpharm.org
In this study, the use of anti-CD3/CD28 magnetic microbeads and IL-15 in the culture of T
lymphocytes in vitro had a significant role in the proliferation and cytotoxicity of these cells …

CMV as culprit or bystander: The debate continues.

M Yamada, R Pellett Madan - Pediatric Transplantation, 2020 - search.ebscohost.com
Consistent with other studies, the risk of CMV infection, defined as asymptomatic CMV
DNAemia, was highest among CMV HR recipients (HR 71%, IR 40%, and LR 18%). Not …