Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

I Akoumianakis, M Polkinghorne… - Nature Reviews …, 2022 - nature.com
WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Epicardial adipose tissue as a mediator of cardiac arrhythmias

KHK Patel, T Hwang, C Se Liebers… - American Journal of …, 2022 - journals.physiology.org
Obesity is associated with higher risks of cardiac arrhythmias. Although this may be partly
explained by concurrent cardiometabolic ill-health, growing evidence suggests that …

Are interactions between epicardial adipose tissue, cardiac fibroblasts and cardiac myocytes instrumental in atrial fibrosis and atrial fibrillation?

A Krishnan, E Chilton, J Raman, P Saxena… - Cells, 2021 - mdpi.com
Atrial fibrillation is very common among the elderly and/or obese. While myocardial fibrosis
is associated with atrial fibrillation, the exact mechanisms within atrial myocytes and …

Epicardial adipose tissue and atrial fibrillation: possible mechanisms, potential therapies, and future directions

M Zhou, H Wang, J Chen, L Zhao - Pacing and Clinical …, 2020 - Wiley Online Library
Obesity plays an important role in the pathogenesis of atrial fibrillation (AF). Recently, rather
than general fat distribution, epicardial adipose tissue (EAT) gains a growing concern. EAT …

The role of epicardial adipose tissue in the development of atrial fibrillation, coronary artery disease and chronic heart failure in the context of obesity and type 2 …

A Krishnan, H Sharma, D Yuan, AF Trollope… - Journal of …, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are a significant burden globally and are especially
prevalent in obese and/or diabetic populations. Epicardial adipose tissue (EAT) surrounding …

Cardiolipotoxicity, inflammation, and arrhythmias: role for interleukin-6 molecular mechanisms

A Alí, M Boutjdir, AS Aromolaran - Frontiers in physiology, 2019 - frontiersin.org
Fatty acid infiltration of the myocardium, acquired in metabolic disorders (obesity, type-2
diabetes, insulin resistance, and hyperglycemia) is critically associated with the …

The role and implications of epicardial fat in coronary atherosclerotic disease

L Braescu, M Gaspar, D Buriman, OM Aburel… - Journal of Clinical …, 2022 - mdpi.com
The current minireview aims to assess the implications of epicardial fat secretory function in
the development of coronary artery disease. The epicardial adipose tissue (EAT) is a …

Understanding arrhythmogenic cardiomyopathy: advances through the use of human pluripotent stem cell models

CJ Chua, J Morrissette-McAlmon, L Tung, KR Boheler - Genes, 2023 - mdpi.com
Cardiomyopathies (CMPs) represent a significant healthcare burden and are a major cause
of heart failure leading to premature death. Several CMPs are now recognized to have a …

Update on the diagnostic pitfalls of autopsy and post-mortem genetic testing in cardiomyopathies

S Grassi, O Campuzano, M Coll, F Cazzato… - International Journal of …, 2021 - mdpi.com
Inherited cardiomyopathies are frequent causes of sudden cardiac death (SCD), especially
in young patients. Despite at the autopsy they usually have distinctive microscopic and/or …

A new therapeutic framework for atrial fibrillation drug development

YS Ang, S Rajamani, SM Haldar, J Hueser - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia and cause of significant
morbidity and mortality. Its increasing prevalence in aging societies constitutes a growing …