Group A Streptococcus adaptation to diverse niches: lessons from transcriptomic studies

L Schiavolin, G Deneubourg, J Steinmetz… - Critical reviews in …, 2024 - Taylor & Francis
Abstract Group A Streptococcus (GAS) is a major human pathogen, causing diseases
ranging from mild superficial infections of the skin and pharyngeal epithelium to severe …

Systematic elucidation of independently modulated genes in Lactiplantibacillus plantarum reveals a trade‐off between secondary and primary metabolism

S Qiu, Y Huang, S Liang, H Zeng… - Microbial …, 2024 - Wiley Online Library
Lactiplantibacillus plantarum is a probiotic bacterium widely used in food and health
industries, but its gene regulatory information is limited in existing databases, which …

Meta-analysis Driven Strain Design for Mitigating Oxidative Stresses Important in Biomanufacturing

PV Phaneuf, SH Kim, K Rychel, C Rode… - ACS Synthetic …, 2024 - ACS Publications
As the availability of data sets increases, meta-analysis leveraging aggregated and
interoperable data types is proving valuable. This study leveraged a meta-analysis workflow …

[HTML][HTML] Streptolysin S is required for Streptococcus pyogenes nasopharyngeal and skin infection in HLA-transgenic mice

BA Shannon, JR Hurst, RS Flannagan, HC Craig… - PLoS …, 2024 - journals.plos.org
Streptococcus pyogenes is a human-specific pathogen that commonly colonizes the upper
respiratory tract and skin, causing a wide variety of diseases ranging from pharyngitis to …

Machine learning analysis of RB-TnSeq fitness data predicts functional gene modules in Pseudomonas putida KT2440

AJ Borchert, AC Bleem, HG Lim, K Rychel, KD Dooley… - Msystems, 2024 - Am Soc Microbiol
There is growing interest in engineering Pseudomonas putida KT2440 as a microbial
chassis for the conversion of renewable and waste-based feedstocks, and metabolic …

Independent component analysis reveals 49 independently modulated gene sets within the global transcriptional regulatory architecture of multidrug-resistant …

ND Menon, S Poudel, AV Sastry, K Rychel, R Szubin… - Msystems, 2024 - Am Soc Microbiol
Acinetobacter baumannii causes severe infections in humans, resists multiple antibiotics,
and survives in stressful environmental conditions due to modulations of its complex …