Oral anticoagulants (OAs) are the recommended drugs to prevent cardiovascular events and
recurrence in patients with atrial fibrillation (AF) and cardioembolic stroke. We conducted a …

Ischaemic stroke is a complex disease with some degree of heritability. This means that
heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of …

Background Recently, using the patient's genotype to guide warfarin dosing has gained
interest; however, whether pharmacogenetics-based dosing (PD) improves clinical …

Pharmacogenomics has been implicated in the response variability of antiplatelet drugs in
coronary artery disease (CAD), particularly for aspirin and clopidogrel. A large number of …

Arterial thrombosis is a major component of vascular disease, especially myocardial
infarction (MI) and stroke. Current anti-thrombotic therapies such as warfarin and clopidogrel …

The incorporation of precision medicine into the clinical setting is becoming increasingly
feasible with the availability of more affordable genetic sequencing technologies and …

Acenocoumarol and warfarin are among the most frequently used oral anticoagulants (OA)
in the entire world. Their therapeutic index is narrow and there are many factors, including …

Stroke is the third cause of mortality and one of most frequent causes of long‐term
neurological disability, as well as a complex disease that results from the interaction of …

Pharmacogenomics of today has its origins in the 1950s with pioneering studies of
monogenic variations in drug metabolism and pharmacokinetics. With the completion of the …

This chapter focuses on acute ischemic stroke: initial evaluation and management,
treatment, epidemiology, outcomes, pathophysiology, risk factors, and stroke syndromes …