Following an overview of the biochemistry of mitogen-activated protein kinase (MAPK)
pathways, the relevance of these signaling events to specific models of renal cell function …

Ochratoxin A (OTA) is a ubiquitous fungal metabolite with nephritogenic, carcinogenic, and
teratogenic action. Epidemiological studies indicate that OTA may be involved in the …

Objective LC-MS/MS phospho-proteomics is an essential technology to help unravel the
complex molecular events that lead to and propagate cancer. We have developed a global …

Renal failure, both acute and chronic, represents an important health problem by its social,
sanitary and economic aspects. Mitogen-activated protein kinases (MAPK) are a family of …

Ochratoxin A (OTA) is a mycotoxin often found in cereals and agricultural products. There is
unequivocal evidence of renal carcinogenicity of OTA in male rats, although the mechanism …

Our current approach focused on the identification of potential early protein biomarker
signatures which are indicative of the carcinogenic processes in rats exposed to 20 mg/kg of …

The objective of this study was to understand the possible mechanisms of activation of
receptor EphA2 by its ligand ephrinA1 in malignant mesothelioma cell (MMC) growth …

During certain developmental processes, as well as during tumor progression, polarized
epithelial cells integrated within multicellular structures convert into scattered, freely …

Constitutive activation of the MAPK/ERK kinase (MEK) 1-ERK2 signaling module in Madin-
Darby canine kidney (MDCK)-C7 cells disrupts their ability to form cystlike structures in …

The kidneys represent one of the main targets of ochratoxin A (OTA), a secondary fungal
metabolite that is produced by certain species of Aspergillus and Penicillium. OTA has the …